Volume 19, No. 2, 2022
Effectiveness Of Maitland’s Mobilization And Conventional Physical Therapy On Synovial Biomarkers In Patients With Knee Osteoarthritis; A Randomized Control Trial
Maryam Shabbir, PT , Dr. Irum Gul , Dr. Ejaz Asghar , Dr. Noor Muhammad , Hafiza Mehjabeen, PT , Imran Rafiq, PT & Naveed Arshad, PT
Abstract
Objectives: To determine the effects of Maitland mobilization and conventional physical therapies on synovial biomarkers, pain, and functional performance in the patients with knee osteoarthritis. Methods: A total of 70 eligible patients with knee osteoarthritis, randomly allocated into Group “A” (n=36) undergoing conventional physiotherapy and Group “B” (n=36) implementing Maitland’s mobilization for three months. Hyaluronic acid and C-reactive protein levels measured by ELISA method, pain by Numeric pain rating sale and functional performance measured on Western Ontario and McMaster Universities Arthritis Index, instituted at baseline, 6th and 12th weeks of treatment. Results: Comparison between group A and B was found non-significant with p-value >0.05 in NPRS, WOMAC and C Reactive Protein at baseline time point. At 18th week assessment, NPRS had statistically significant differences by p-value=0.026, whereas WOMAC, C Reactive Protein and Hyaluronic Acid were also indicated highly significant difference by p-value <0.001. For within group comparison at different time points (at base line, 6th, 12th and 18th week) in group A and B, statistically significant difference with p-value <0.001 in NPRS, WOMAC, C Reactive Protein and Hyaluronic Acid for Synovial biomarkers was observed. Conclusion: Maitland mobilization results in significant reduction in the values of inflammatory biomarkers including hyaluronic acid and C-reactive protein as well as pain and improvements in functional performance as compared to the conventional physical therapy management in subjects with knee osteoarthritis.
Pages: 9924-9937
Keywords: Synovial Biomarkers, C-reactive protein, Hyaluronic acid, Pain, Physical Functional Performance, knee Osteoarthritis.